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Discovery, Synthesis and Mechanism Study of 2,3,5-Substituted [1,2,4]-Thiadiazoles As Covalent Inhibitors Targeting 3C-Like Protease of SARS-CoV-2

Pengxuan Ren,Changyue Yu,Ruxue Zhang,Tianqing Nie,Qiaoyu Hu,Hui Li,Xianglei Zhang, Xueyuan Zhang,Shiwei Li,Lu Liu,Wenhao Dai,Jian Li,Yechun Xu,Haixia Su,Leike Zhang,Hong Liu,Fang Bai

European Journal of Medicinal Chemistry（2023）

Cited 8|Views40
Key words
SARS-CoV-2,3CLpro,Covalent inhibitors,2,3,5-substituted [1,2,4]-thiadiazole,Warhead,Ring-opening metathesis
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