The Ixodes ricinus salivary gland proteome during feeding and B. Afzelii infection: New avenues for an anti-tick vaccine

Michelle J Klouwens,Jos J A Trentelman,Diego Barriales,Jasmin I Ersoz,Mikel Azkargorta,Felix Elortza,Radek Šíma,Ondrej Hajdušek,José-Luis Lavin, Julen Tomás Cortazar, Iraide Escobes Corcuera, Emil Colstrup,Abhijeet Nayak,Itziar Martín Ruíz,Hector Rodriguez,Ard M Nijhof,Juan Anguita,Joppe W R Hovius

Vaccine（2023）

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摘要

Using quantitative proteomics, we identified differential protein production in I. ricinus salivary glands in response to B. afzelii infection and different feeding conditions. These results provide novel insights into the process of I. ricinus feeding and B. afzelii transmission and revealed novel candidates for an anti-tick vaccine.

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关键词

Borrelia afzelii,Proteomics,Ixodes ricinus,Salivary glands,Feeding,Anti-tick vaccines

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