Humoral and cellular immune responses in persons with rheumatoid arthritis after a third dose of mRNA COVID-19 vaccine

Sara K Tedeschi,Daniel H Solomon,Yuezhou Chen,Jack Ellrodt,Mary Grace Whelan,Jacklyn Stratton,Keigo Hayashi,Noah Benjamin Whiteman,Lin Chen,Ifeoluwakiisi Adejoorin,Kathryne E Marks,Emma Gomez-Rivas,Deepak A Rao,A Helena Jonsson,Duane R Wesemann

Seminars in Arthritis and Rheumatism（2023）

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摘要

Virus-specific IgG levels significantly increased in RA subjects using DMARDs after completing the primary vaccine series, though fewer than two-thirds achieved a humoral response like healthy controls. Humoral and cellular changes were not correlated.

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关键词

Rheumatoid arthritis,COVID-19,Vaccine,Humoral immunity,Cellular immunity,DMARDs,Immunosuppression

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