CD8 + T Cells Promote Pathological Angiogenesis in Ocular Neovascular Disease.

Devy Deliyanti,William A Figgett,Thomas Gebhardt,Joseph A Trapani,Fabienne Mackay,Jennifer L Wilkinson-Berka

Arteriosclerosis, thrombosis, and vascular biology（2023）

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摘要

We discovered that CXCR3 is central to the migration of CD8 T cells into the retina as the CXCR3 blockade reduced the number of CD8 T cells within the retina and vasculopathy. This research identified an unappreciated role for CD8 T cells in retinal inflammation and vascular disease. Reducing CD8 T cells via their inflammatory and recruitment pathways is a potential treatment for neovascular retinopathies.

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flow cytometry,granzymes,mice,perforin,retinal neovascularization

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