Prevalent Pseudoprogression and Pseudoresidue in Patients With Rectal Cancer Treated With Neoadjuvant Immune Checkpoint Inhibitors.

Yumo Xie,Jinxin Lin,Ning Zhang,Xiaolin Wang,Puning Wang,Shaoyong Peng,Juan Li,Yuanhui Wu,Yaoyi Huang,Zhuokai Zhuang,Dingcheng Shen,Mingxuan Zhu,Xiaoxia Liu,Guangjian Liu,Xiaochun Meng,Meijin Huang,Huichuan Yu,Yanxin Luo

Journal of the National Comprehensive Cancer Network : JNCCN（2023）

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摘要

Pseudoprogression and pseudoresidue were unique and prevalent response patterns in MSI-H/dMMR rectal cancer after nICI treatment. Our findings highlight the importance of developing specific strategies for response evaluation in neoadjuvant immunotherapy to identify patients with a good response in whom sphincter/organ-preserving or watch-and-wait strategies may be considered.

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关键词

Neoadjuvant therapy,Organ preservation,PD-1,rectal cancer

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