Implementation and clinical benefit of DPYD genotyping in a Danish cancer population.

N H Paulsen,P Pfeiffer,M Ewertz, P B N Fruekilde,S Feddersen, H S Holm,T K Bergmann,C Qvortrup,P Damkier

ESMO open（2023）

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摘要

We found no population-level benefit of DPYD genotyping when comparing the risk of grade ≥3 FP-TOX before and after clinical implementation. We observed no deaths or FP-related hospitalizations in patients whose FP treatment was guided by a variant DPYD genotype. The use of DPD phenotyping may add valuable information in DPYD wild-type patients.

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关键词

DPD deficiency,DPD phenotype,DPYD genotype

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