Development and validation of a mass spectrometry based analytical method to quantify the ratios in hemagglutinin trimers in quadrivalent influenza nanoparticle vaccine - FluMos-v1.

Asif Shajahan,Cindy X Cai,Jeremy Wolff, R Sylvie Yang,Vera B Ivleva,Daniel B Gowetski,Jason G D Gall,Q Paula Lei

Analytical methods : advancing methods and applications（2023）

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摘要

A quadrivalent influenza nanoparticle vaccine (FluMos-v1) offers long-lasting protection against multiple influenza virus strains and is composed of four strains of hemagglutinin trimer (HAT) assembled around a pentamer core. Here we report an LC-MS/MS analytical development and validation method to measure the percentage of each HAT component in FluMos-v1.

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关键词

quadrivalent influenza nanoparticle vaccine,hemagglutinin trimers,mass spectrometry

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