A neglected and emerging antimicrobial resistance gene encodes for a serine-dependent macrolide esterase.

Poonam Dhindwal, Charis Thompson, Daniel Kos, Koa Planedin, Richa Jain,Murray Jelinski,Antonio Ruzzini

Proceedings of the National Academy of Sciences of the United States of America（2023）

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摘要

The discovery of unreported antimicrobial resistance genes (ARGs) remains essential. Here, we report the identification and preliminary characterization of an α/β-hydrolase that inactivates macrolides. This serine-dependent macrolide esterase co-occurs with emerging ARGs in the environment, animal microbiomes, and pathogens.

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关键词

antimicrobial resistance,esterase,hydrolase,macrolides

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