The Prevention Effect of Lactobacillus plantarum 17–5 on Escherichia coli -Induced Mastitis in Mice

Mastitis is the most economically important disease affecting the dairy industry worldwide. Lactobacillus plantarum , an important probiotic with a wide range of applications, has potential anti-inflammatory properties and has become a currently strong candidate for mastitis therapies. In the current study, we evaluated the prevention effect of Lactobacillus plantarum 17–5 on Escherichia coli -induced mastitis in mice. The results showed that pretreatment with L. plantarum 17–5 maintained the integrity of tight junctions; improved inflammatory injury; decreased MPO activity and the mRNA expression levels of IL1β , IL6 , and TNFα ; and inhibited the NF-κB and MAPK signaling pathways in mice mammary tissue. The results indicated that Lactobacillus plantarum 17–5 had excellent anti-inflammatory activities and could be developed into microecological preparation for clinical use to prevent mastitis.