Investigation of Shared Genetic Risk Factors Between Parkinson's Disease and Cancers.

Pierre-Emmanuel Sugier,Elise A Lucotte,Cloé Domenighetti,Matthew H Law,Mark M Iles,Kevin Brown,Christopher Amos,James D McKay,Rayjean J Hung,Mojgan Karimi,Delphine Bacq-Daian,Anne Boland-Augé,Robert Olaso,Jean-François Deleuze,Fabienne Lesueur,Evgenia Ostroumova,Ausrele Kesminiene,Florent de Vathaire,Pascal Guénel,Ashwin Ashok Kumar Sreelatha,Claudia Schulte,Sandeep Grover,Patrick May,Dheeraj R Bobbili,Milena Radivojkov-Blagojevic,Peter Lichtner,Andrew B Singleton,Dena G Hernandez,Connor Edsall,George D Mellick,Alexander Zimprich,Walter Pirker,Ekaterina Rogaeva,Anthony E Lang,Sulev Koks,Pille Taba,Suzanne Lesage,Alexis Brice,Jean-Christophe Corvol,Marie-Christine Chartier-Harlin,Eugénie Mutez,Kathrin Brockmann,Angela B Deutschländer,Georges M Hadjigeorgiou,Efthimios Dardiotis,Leonidas Stefanis,Athina Maria Simitsi,Enza Maria Valente,Simona Petrucci,Letizia Straniero,Anna Zecchinelli,Gianni Pezzoli,Laura Brighina,Carlo Ferrarese,Grazia Annesi,Andrea Quattrone,Monica Gagliardi,Hirotaka Matsuo,Akiyoshi Nakayama,Nobutaka Hattori,Kenya Nishioka,Sun Ju Chung,Yun Joong Kim,Pierre Kolber,Bart P C van de Warrenburg,Bastiaan R Bloem,Jan Aasly,Mathias Toft,Lasse Pihlstrøm,Leonor Correia Guedes,Joaquim J Ferreira,Soraya Bardien,Jonathan Carr,Eduardo Tolosa,Mario Ezquerra,Pau Pastor,Monica Diez-Fairen,Karin Wirdefeldt,Nancy Pedersen,Caroline Ran,Andrea C Belin,Andreas Puschmann,Emil Ygland Rödström,Carl E Clarke,Karen E Morrison,Manuela Tan,Dimitri Krainc,Lena F Burbulla,Matt J Farrer,Rejko Kruger,Thomas Gasser,Manu Sharma,Thérèse Truong,Alexis Elbaz

Movement disorders : official journal of the Movement Disorder Society（2023）

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摘要

We show evidence in favor of a contribution of pleiotropic genes to the association between PD and specific cancers. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.

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关键词

Parkinson's disease,cancer,genetic correlation,pleiotropy,polygenic risk score

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