Activation of Angiopoietin-Tie2 Signaling Protects the Kidney from Ischemic Injury by Modulation of Endothelial-Specific Pathways.

Yanyang Li,Pan Liu,Yalu Zhou,Hiroshi Maekawa, John B Silva,Mohammed Javeed Ansari,Khaled Boubes, Yazan Alia,Dilip K Deb,Benjamin R Thomson,Jing Jin,Susan E Quaggin

Journal of the American Society of Nephrology : JASN（2023）

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摘要

Our data support a key role of the endothelium in the development of IR-AKI, introduce Hepta-ANG1 as a putative new therapeutic biologic, and report a model to explain how IRI reduces Tie2 signaling and how Tie2 activation protects the kidney.

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关键词

ischemic injury,kidney,angiopoietin-tie,endothelial-specific

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