A Review of Pregnancy Outcomes in Pregnant Women Vaccinated Against COVID-19

Background: Evidence has shown that the COVID-19 pandemic can have unpleasant side effects for pregnant women and fetuses. Therefore, vaccination of pregnant women was performed to make this group safe. In order to consolidate the existing knowledge about the effectiveness and consequences of pregnancy in women who underwent this vaccination, this study was designed and implemented. Methods: In this systematic review study, all published studies up to 24.2.2022 were included in the study. The studies were searched in the databases of Embase, PubMed, Web of Science, Scopus using the keywords Pregnancy, COVID-19 Virus Vaccines, Pregnancy Complications and fetal outcome. The two researchers independently reviewed the articles for quality assessment (using the Newcastle-Ottawa tool) and extracted their main findings. Findings: In this review study, 10 studies were included in accordance with the inclusion criteria with 40522 pregnant women who received the COVID-19 vaccine. The incidence of maternal complications after vaccination was extremely low. Among pregnant women, there was no significant difference in maternal complications based on whether the vaccine was given in the first, second or third trimester of pregnancy. Covid-19 vaccination during pregnancy was not associated with an increase in pregnancy complications or delivery. Conclusion: Considering that the safety and efficacy of COVID-19 vaccine are important factors in achieving population immunity, more acceptance of vaccines is essential to achieve adequate immunization coverage. Health care providers can use the available data to educate and empower pregnant women to make informed decisions.