Selenylated indoles: synthesis, effects on lipid membrane properties and DNA cleavage

Gabriela J. Pedroso, Desiree M. S. Costa,Lucas T. Felipe Kokuszi,Eduardo B. V. da Silva, Marcos F. O. Cavalcante,Eduardo Junca,Cassio A. O. Moraes,Claus T. Pich,Vania R. De Lima,Sumbal Saba,Jamal Rafique,Tiago E. A. Frizon

NEW JOURNAL OF CHEMISTRY（2023）

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摘要

In this report, we evaluated the effects of selenylated indoles (3a-d) on lipid membranes and their capacity to interact with DNA. These selenylated indoles increased the motion rate of the polar region of lipids and compounds 3b-d ordered the non-polar region. The DNA cleavage ability was observed only for 3c.

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关键词

selenylated indoles,lipid membrane properties

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