Subpopulation Heterogeneity of NK Cells during the Genetic Modification for Subsequent Use in Targeted Therapy

M. A. Streltsova, A. A. Boyko,M. O. Ustiuzhanina, A. I. Palamarchuk, N. A. Alekseeva, R. A. Velichinskii, J. D. Vavilova, M. V. Grechikhina,A. M. Sapozhnikov, S. M. Deev,E. I. Kovalenko

Doklady Biochemistry and Biophysics（2022）

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摘要

Obtaining genetically engineered NK cells is a developing area of immunotherapy. In this work, we analyzed the subset heterogeneity of NK cells subjected to retroviral transduction, taking into account the content of adaptive NK cell progenitors. It was shown that subsets KIR2DL2/DL3+, as well as CD57–KIR2DL2/DL3+NKG2C+, can be modified with greater efficiency than the corresponding subsets that do not carry the KIR2DL2/DL3 and NKG2C markers. After genetic modification, the CD57–KIR2DL2/DL3+NKG2C+ cells began to express CD57 de novo, acquiring the adaptive NK cell phenotype.

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关键词

NK cells,immunotherapy,modification,transduction,adaptive NK cells,proliferative potential,sensitivity to modification

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