PGAM5 expression levels in heart failure and protection ROS-induced oxidative stress and ferroptosis by Keap1/Nrf2.

Shuangfei Li, Ping Wen,Dayong Zhang,Decai Li, Qidong Gao,Hong Liu, Yunfeng Di

Clinical and experimental hypertension (New York, N.Y. : 1993)（2023）

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摘要

We conclude that the protection of PGAM5 reduced ROS-induced oxidative stress and ferroptosis by the Keap1/Nrf2 signaling pathway in heart failure, suggesting that targeting this mechanism of PGAM5 may be a feasible strategy to treat heart failure.

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关键词

Keap1,Nrf2,PGAM5,ferroptosis,heart failure

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