Targeting Notch1-YAP Circuit Reprograms Macrophage Polarization and Alleviates Acute Liver Injury in Mice.

Yan Yang,Ming Ni,Ruobin Zong,Mengxue Yu,Yishuang Sun,Jiahui Li,Pu Chen,Changyong Li

Cellular and molecular gastroenterology and hepatology（2023）

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摘要

Our findings underscore a novel molecular insight into the Notch1-YAP circuit for controlling macrophage polarization in acute liver injury, raising the possibility of targeting macrophage Notch1-YAP circuit as an effective strategy for liver inflammation-related diseases.

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关键词

Acute Liver Injury,Liver Inflammation,Macrophage Polarization,Notch Signaling,YAP

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