Diastereoselective Alkylation of Activated Nitrogen Heterocycles with Alkenyl Boronate Complexes.
Angewandte Chemie (International ed. in English)(2023)
摘要
Alkenyl boronate complexes react with acylated quinolines and isoquinolines via 1,2-metalate rearrangement to give alkylated, dearomatized heterocycles in good yields, diastereoselectivities, and regioselectivities. This multi-component coupling is highly modular and can be used to access a wide scope of heterocyclic scaffolds. Chiral boronic esters made through this methodology possess high synthetic potential and can be transformed into various functional groups in one step without racemization.
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关键词
Alkenyl Boronate,Isoquinolines,Multicomponent Coupling,Quinolines
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