SHP-2-induced M2 polarization of tumor associated macrophages via IL-4 regulate colorectal cancer progression.

Zhihan Li,Jinchuan Xi,Baokun Li,Youqiang Liu,Guiying Wang, Bin Yu,Hongqing Ma, Zhilin Li,Zhenya Zhang

Frontiers in oncology（2023）

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摘要

The low expression of SHP-2 induced by PHPS1 may regulate M2 polarization of TAMs and release of exosomes through PI3K/AKT pathway, thereby enhancing the migration and invasion ability of CRC cells.

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关键词

Src homology region 2 domain-containing protein tyrosine phosphatase-2,colorectal cancer,invasion,migration,tumor-associated macrophages

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