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Clinicopathologic and Genomic Factors Impacting Efficacy of First-Line Chemoimmunotherapy in Advanced NSCLC.

Joao V Alessi,Arielle Elkrief,Biagio Ricciuti,Xinan Wang,Alessio Cortellini,Victor R Vaz,Giuseppe Lamberti, Rosa L Frias,Deepti Venkatraman,Claudia A M Fulgenzi,Federica Pecci,Gonzalo Recondo,Alessandro Di Federico,Adriana Barrichello,Hyesun Park,Mizuki Nishino, Grace M Hambelton,Jacklynn V Egger,Marc Ladanyi,Subba Digumarthy,Bruce E Johnson,David C Christiani,Xihong Lin,Justin F Gainor,Jessica J Lin,David J Pinato,Adam J Schoenfeld,Mark M Awad

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer（2023）

引用 8|浏览21
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摘要
In advanced NSCLC, better patient performance status, low derived neutrophil-to-lymphocyte ratio, increasing PD-L1 expression, a very high TMB, and STK11/KEAP1/SMARCA4 wild-type status are associated with improved clinical outcomes to first-line CIT.
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关键词
Chemoimmunotherapy,First-line,KRAS,NSCLC,PD-L1 expression,Tumor mutational burden
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