Progess in the synthesis of chiral tetrahedroquinoline derivatives from asymmetric inverse electron-demand aza-Diels-Alder reaction

Abstract： Optically active tetrahydroquinoline derivatives have attracted considerable attention due to their important biological activities. For their construction, catalytic asymmetric inverse electron-demand aza-Diels-Alde reaction of N-arylimines with electron-rich alkenes (dienophiles) has been demonstrated to be one of the most powerful strategies. In this article, the progress of asymmetric catalytic inverse electron-demand aza-Diels-Alder is summarized according to the kind of the dienophiles. The future of the development of the reaction is also discussed.