Nonlinear Simulation of Modulation Pulse Sequencing for Contrast-Enhanced Ultrasound (CEUS) Imaging

Microbubble nonlinearita based contrast-enhanced ultrasound (CEUS) imaging has received extensive attentions due to its high scattering and resonance for facilitating blood flow imaging. In contrast to soft tissues, microbubble echoes are rich in harmonic components because of periodic expansion and contraction movements. Different Contrast Pulse Sequence (CPS) strategies have been developed for nonlinear ultrasound imaging. In present study, a modified Rayleigh-Plesset equation based numerical simulation method is applied to investigate performances of nonlinear ultrasound imaging with different CPS strategies.