Comment on the upper cutoff level for the alcohol biomarker phosphatidylethanol (PEth) for the assessment of alcohol consumption in forensic practice

DRUG TESTING AND ANALYSIS(2023)

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Drug Testing and AnalysisVolume 15, Issue 7 p. 791-792 LETTER TO THE EDITOR Comment on the upper cutoff level for the alcohol biomarker phosphatidylethanol (PEth) for the assessment of alcohol consumption in forensic practice Frank Musshoff, Corresponding Author Frank Musshoff [email protected] orcid.org/0000-0002-9613-0525 Forensisch Toxikologisches Centrum GmbH, Munich, Germany Correspondence Frank Musshoff, Forensisch Toxikologisches Centrum GmbH, Dessauerstr. 13-15, 80992 Munich, Germany. Email: [email protected]Search for more papers by this authorMichael Böttcher, Michael Böttcher MVZ Labor Dessau GmbH, Dessau-Roßlau, GermanySearch for more papers by this authorMatthias Graw, Matthias Graw Institute of Legal Medicine, Ludwig-Maximilians-University of Munich, Munich, GermanySearch for more papers by this authorGisela Skopp, Gisela Skopp Forensisch Toxikologisches Centrum GmbH, Munich, GermanySearch for more papers by this authorJasna Neumann, Jasna Neumann MVZ Labor Dessau GmbH, Dessau-Roßlau, GermanySearch for more papers by this authorGudrun Høiseth, Gudrun Høiseth Department of Forensic Sciences, Oslo University Hospital, Oslo, NorwaySearch for more papers by this authorAnders Helander, Anders Helander orcid.org/0000-0001-7480-8078 Department of Laboratory Medicine, C1:74, Karolinska University Hospital, Karolinska Institutet, Stockholm, SwedenSearch for more papers by this author Frank Musshoff, Corresponding Author Frank Musshoff [email protected] orcid.org/0000-0002-9613-0525 Forensisch Toxikologisches Centrum GmbH, Munich, Germany Correspondence Frank Musshoff, Forensisch Toxikologisches Centrum GmbH, Dessauerstr. 13-15, 80992 Munich, Germany. Email: [email protected]Search for more papers by this authorMichael Böttcher, Michael Böttcher MVZ Labor Dessau GmbH, Dessau-Roßlau, GermanySearch for more papers by this authorMatthias Graw, Matthias Graw Institute of Legal Medicine, Ludwig-Maximilians-University of Munich, Munich, GermanySearch for more papers by this authorGisela Skopp, Gisela Skopp Forensisch Toxikologisches Centrum GmbH, Munich, GermanySearch for more papers by this authorJasna Neumann, Jasna Neumann MVZ Labor Dessau GmbH, Dessau-Roßlau, GermanySearch for more papers by this authorGudrun Høiseth, Gudrun Høiseth Department of Forensic Sciences, Oslo University Hospital, Oslo, NorwaySearch for more papers by this authorAnders Helander, Anders Helander orcid.org/0000-0001-7480-8078 Department of Laboratory Medicine, C1:74, Karolinska University Hospital, Karolinska Institutet, Stockholm, SwedenSearch for more papers by this author First published: 30 December 2022 https://doi.org/10.1002/dta.3432Citations: 2Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat No abstract is available for this article. REFERENCES 1Luginbühl M, Wurst FM, Stöth F, Weinmann W, Stove CP, van Uytfanghe K. Consensus for the use of the alcohol biomarker phosphatidylethanol (PEth) for the assessment of abstinence and alcohol consumption in clinical and forensic practice (2022 Consensus Basel). Drug Testing Anal. 2022; 14(10): 1800-1802. doi:10.1002/dta.3340 2Ulwelling W, Smith K. The PEth blood test in the security environment: what it is; why it is important; and interpretative guidelines. J Forensic Sci. 2018; 63(6): 1634-1640. doi:10.1111/1556-4029.13874 3Helander A, Hansson T. Nationell harmonisering av alkoholmarkören PEth [National harmonization of the alcohol biomarker PEth]. Lakartidningen. 2013; 110(39–40): 1747-1748. PMID: 24245431. 4 Deutsche Gesellschaft für Verkehrspsychologie (DGVP) und Deutsche Gesellschaft für Verkehrsmedizin (DGVM). Urteilsbildung in der Fahreignungsbegutachtung - Beurteilungskriterien, 4. Bonn, Germany: Auflage, Kirschbaum Verlag; 2022. 5Schröck A, Pfäffli M, König S, Weinmann W. Application of phosphatidylethanol (PEth) in whole blood in comparison to ethyl glucuronide in hair (hEtG) in driving aptitude assessment (DAA). Int J Leg Med. 2016; 130(6): 1527-1533. doi:10.1007/s00414-016-1394-4 6Weinmann W, Schröck A, Wurst FM. Commentary on the paper of Walther L. et al.: phosphatidylethanol is superior to CDT and GGT as an alcohol marker and is a reliable estimate of alcohol consumption level. Alcohol Clin Exp Res. 2016; 40(2): 260-262. doi:10.1111/acer.12946 7Helander A, Hermansson U, Beck O. Dose–response characteristics of the alcohol biomarker phosphatidylethanol (PEth)—a study of outpatients in treatment for reduced drinking. Alcohol Alcohol. 2019; 54(6): 567-573. doi:10.1093/alcalc/agz064 8Isaksson A, Walther L, Hansson T, Andersson A, Stenton J, Blomgren A. High-throughput LC-MS/MS method for determination of the alcohol use biomarker phosphatidylethanol in clinical samples by use of a simple automated extraction procedure-preanalytical and analytical conditions. J Appl Lab Med. 2018; 2(6): 880-892. doi:10.1373/jalm.2017.024828 9Årving A, Høiseth G, Hilberg T, et al. Comparison of the diagnostic value of phosphatidylethanol and carbohydrate-deficient transferrin as biomarkers of alcohol consumption. Alcohol Clin Exp Res. 2021; 45(1): 153-162. doi:10.1111/acer.14503 10Neumann J, Beck O, Böttcher M. Phosphatidylethanol, ethyl glucuronide and ethanol in blood as complementary biomarkers for alcohol consumption. J Mass Spectrom Adv Clin Lab. 2021; 22: 3-7. doi:10.1016/j.jmsacl.2021.09.005 11Høiseth G, Hilberg T, Trydal T, Husa A, Vindenes V, Bogstrand ST. The alcohol marker phosphatidylethanol is closely related to AST, GGT, ferritin and HDL-C. Basic Clin Pharmacol Toxicol. 2022; 130(1): 182-190. doi:10.1111/bcpt 12Helander A, Böttcher M, Dahmen N, Beck O. Elimination characteristics of the alcohol biomarker phosphatidylethanol (PEth) in blood during alcohol detoxification. Alcohol Alcohol. 2019; 54(3): 251-257. doi:10.1093/alcalc/agz027 13Gnann H, Weinmann W, Thierauf A. Formation of phosphatidylethanol and its subsequent elimination during an extensive drinking experiment over 5 days. Alcohol Clin Exp Res. 2012; 36(9): 1507-1511. doi:10.1111/j.1530-0277.2012.01768.x Citing Literature Volume15, Issue7July 2023Pages 791-792 ReferencesRelatedInformation
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alcohol biomarker phosphatidylethanol,alcohol consumption
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