Ferrocenoyl Glutathione Modified Electrodes: Fabrication and Application for Detection of Cadmium Ions

Abstract： In this paper, 1’-cysteaminecarbonyl-1-glutathionecarbonyl-ferrocene (Fc-GSH) (4) was firstly synthesized from ferrocene dicarboxylic acid and reduced glutathione (GSH) with several steps. The products were characterized by IR and 1H-NMR. Then Fc-GSH was immobilized on the surface of gold electrode. Cyclic votammetry (CV) was adapted to investigate the electrochemical properties of this Fc-GSH modified electrode in the cadmium ions aqueous solutions. In the presence of cadmium ions,large anodic shift was observed in the experiment. Moreover this shift was proportion to the concentration of Cd2+ when the concentration of cadmium ions is lower than 20 nM. So the modified electrode was used as probes to detect cadmium ions with the limitation of 0.1 nM by cyclic voltammetry.