Cinnamomum cassia Presl flavonoids prevent hyperglycemia-induced cognitive impairment via inhibiting of AGEs accumulation and oxidative stress

Hemei Li, Jinling Zhou,Sitong Liu, Xiuting Chen, Tiantian Qin,Guodong Huang, Peizhen Luo,Ying Hu,Xing Xia

JOURNAL OF FUNCTIONAL FOODS（2023）

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摘要

•Cinnamomum cassia Presl flavonoids (CFS) prevented diabetes-induced cognitive impairment in rats.•CFS alleviated the hippocampal morphology damage and oxidative stress in the rats.•CFS decreased AGEs formation both in vitro and in the hippocampus.•AGEs-RAGE pathway was deactivated by CFS in diabetic rats.

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关键词

Cinnamomum cassia Presl,Flavonoids,Hyperglycemia-induced cognitive impairment,AGEs accumulation,Oxidative stress

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