Humoral and cellular immune responses against SARS-CoV-2 variants of concern induced by heterologous CoronaVac/ChAdOx-1 versus homologous ChAdOx-1 vaccination in the elderly.

Chalerm Liwsrisakun,Supansa Pata,Witida Laopajon,Nuchjira Takheaw,Warawut Chaiwong,Pilaiporn Duangjit,Juthamas Inchai,Kantinan Chuensirikulchai,Passaworn Cheyasawan,Chaicharn Pothirat,Chaiwat Bumroongkit,Athavudh Deesomchok,Theerakorn Theerakittikul,Atikun Limsukon,Pattraporn Tajarernmuang,Nutchanok Niyatiwatchanchai,Konlawij Trongtrakul,Watchara Kasinrerk

Asian Pacific journal of allergy and immunology（2023）

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摘要

In the elderly, heterologous CoVac/ChAd vaccination could induce NAb response against the WT and non-Omicron variants not different from the homologous ChAd/ChAd vaccination. Both regimens could not give adequate NAb of the Omicron strain. The heterologous vaccination, however, induced higher spike-specific Th1 cell response.

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