Muscleblind-like 2 knockout shifts adducin 1 isoform expression and alters dendritic spine dynamics of cortical neurons during brain development.

Chia-Wei Huang,Kuang-Yung Lee, Peng-Tzu Lin,Fang-Shin Nian,Haw-Yuan Cheng,Chien-Hui Chang, Cheng-Yen Liao, Yen-Lin Su,Carol Seah,Ching Li,Yu-Fu Chen,Mei-Hsuan Lee,Jin-Wu Tsai

Neuropathology and applied neurobiology（2023）

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摘要

MBNL2 plays a critical role in maintaining the dynamics and homeostasis of dendritic spines in the developing brain. Mis-splicing of downstream ADD1 may account for the alterations and contribute to the DM brain pathogenesis.

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关键词

Add1,adducin,alternative splicing,dendritic spine,muscleblind-like,myotonic dystrophy,neural development

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