Analysis of miR-203a-3p/SOCS3-mediated induction of M2 macrophage polarization to promote diabetic wound healing based on epidermal stem cell-derived exosomes.

Hao Yang,Hailin Xu,Zhiyong Wang,Xiaohui Li,Peng Wang,Xiaoling Cao,Zhongye Xu,Dongming Lv,Yanchao Rong,Miao Chen,Bing Tang,Zhicheng Hu,Wuguo Deng,Jiayuan Zhu

Diabetes research and clinical practice（2023）

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摘要

Our results demonstrated that the abundant miR-203a-3p present in EpiSC-EXOs can promote M2 macrophage polarization by downregulating SOCS3 and suggested that diabetic wounds can obtain better healing effects through this mechanism.

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关键词

Diabetic wound,Exosomes,Macrophage,Stem cell,miRNA

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