In vitro myogenesis activation of specific muscle-derived stem cells from patients with Duchenne muscular dystrophy

•The MDSCs isolated from patients with DMD can self-differentiate into myotubes in GM, and can robustly differentiate into myotubes in DM, where their control counterparts do not.•This characteristic, termed “myogenesis activation,” may promote the depletion of MPCs.•This study also successfully established a human cellular model that will enable further research on DMD pathogenesis and therapies.