Fexofenadine protects against lipopolysaccharide-induced acute lung injury by targeting cytosolic phospholipase A2

Yuehong Chen,Huan Liu,Yunru Tian,Zhongling Luo,Jingjing Ran,Zhiyong Miao,Qiuping Zhang,Geng Yin,Qibing Xie

International Immunopharmacology（2023）

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摘要

•FFD reduced macrophage and neutrophil infiltration in lung tissue.•FFD inhibited the production of cytokines and chemokines.•FFD reduced downstream hydrolysis of cPLA2 arachidonic acid and leukotriene B4.•FFD inhibited LPS-induced cPLA2/ERK/P65 signaling pathway by targeting cPLA2.

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关键词

Acute lung injury,Cytosolic phospholipase A2,Fexofenadine,Lipopolysaccharide

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