Genome-wide epigenetic and mRNA-expression profiling followed by CRISPR/Cas9-mediated gene-disruptions corroborate the MIR141/MIR200C -ZEB1/ZEB2-FGFR1 axis in acquired EMT-associated EGFR TKI-resistance in NSCLC cells.

Johan Vad-Nielsen,Nicklas Heine Staunstrup,Magnus Lindkvist Kjeldsen,Nina Dybdal, Guillaume Flandin, Claudia De Stradis,Tina Fuglsang Daugaard,Trine Vilsbøll-Larsen,Christoffer Trier Maansson,Thomas Koed Doktor,Boe Sandahl Sorensen,Anders Lade Nielsen

Translational lung cancer research（2023）

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摘要

The current study describes the synchronous genome-wide changes in mRNA-expression, DNA-methylation, and H3K36me3 in NSCLC EMT-E-TKI-R. The omics approaches revealed potential novel diagnostic markers and treatment targets. Besides, the study consolidates the functional impact of the -ZEB1/ZEB2-FGFR1-signaling axis in NSCLC EMT-E-TKI-R.

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关键词

Non-small cell lung cancer (NSCLC),epigenetics,epithelial-mesenchymal-transition (EMT),tyrosine kinase inhibitor-resistance (TKI-resistance)

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