Effects and mechanisms of Celastrol on the formation of neutrophil extracellular traps (NETs).

The molecular mechanism of Celastrol involves inhibition of PMA-stimulated neutrophil NETs formation , which is possibly related to the reduction of ROS levels. This indicates that Celastrol, the main component in Tripterygium wilfordii, can inhibit the formation of NETs, which provides a theoretical basis for the study of NETs-related diseases.