Morita-Baylis-Hillman adduct 2-(3-hydroxy-2-oxoindolin-3-yl)acrylonitrile (ISACN) modulates the inflammatory process during LPS-induced acute lung injury.

Juliane Santos de França da Silva,Deyse Cristina Madruga Carvalho,Luiz Henrique Agra Cavalcante-Silva,Éssia de Almeida Lima,José Marreiro de Sales Neto,Larissa Adilis Maria Paiva Ferreira,Tayná Rodrigues Olegário,Rhuan Karlos Santos Mendes,Aline Portantiolo Lettnin,Ana Paula de Souza Votto,Mário Luiz Araújo de Almeida Vasconcellos,Claudio Gabriel Lima-Junior,Sandra Rodrigues-Mascarenhas

Immunopharmacology and immunotoxicology（2023）

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摘要

Thus, this work showed for the first time the immunomodulatory action of MBHA in LPS-induced acute lung injury and provided new evidence for the mechanisms related to the anti-inflammatory effect of ISACN.

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ALI,ARDS,MBHA,immunomodulation,isatin

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