tRNA-derived small RNA, 5'tiRNA-Gly-CCC, promotes skeletal muscle regeneration through the inflammatory response.

Linyuan Shen,Tianci Liao,Qiuyang Chen,Yuhang Lei,Linghui Wang,Hao Gu,Yanhao Qiu,Ting Zheng,Yiting Yang, Chenggang Wei,Lei Chen,Ye Zhao,Lili Niu,Shunhua Zhang, Yan Zhu,Mingzhou Li,Jinyong Wang,Xuewei Li,Mailin Gan,Li Zhu

Journal of cachexia, sarcopenia and muscle（2023）

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摘要

These results reveal that 5'tiRNA-Gly potentially regulated skeletal muscle regeneration by inducing inflammation via the TGF-β signalling pathway. The findings of this study uncover a new potential target for skeletal muscle regeneration treatment.

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关键词

TGF-β signalling pathway,Tgfbr1,inflammation,skeletal muscle regeneration,tsRNAs

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