Mutated HRAS Activates YAP1-AXL Signaling to Drive Metastasis of Head and Neck Cancer.

Sankar Jagadeeshan,Manu Prasad,Mai Badarni, Talal Ben-Lulu,Vijayasteltar Belsamma Liju,Sooraj Mathukkada, Claire Saunders,Avital Beeri Shnerb,Jonathan Zorea,Ksenia M Yegodayev, Monica Wainer, Liza Vtorov,Irit Allon,Ofir Cohen, Gro Gausdal,Dinorah Friedmann-Morvinski,Sok Ching Cheong,Alan L Ho,Ari J Rosenberg,Linda Kessler,Francis Burrows,Dexin Kong,Jennifer R Grandis,J Silvio Gutkind,Moshe Elkabets

Cancer research（2023）

引用 3|浏览23

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摘要

Mutant HRAS drives metastasis of head and neck cancer by switching off the Hippo pathway to activate the YAP1-AXL axis and to stimulate lymphovascular angiogenesis.

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关键词

hras activates yap1–axl,neck cancer,metastasis,head

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