Procalcitonin as a biomarker for predicting bacterial infection in chimeric antigen receptor T-cell therapy recipients.

Marissa Z Powell,Kristin C Mara,Radhika Bansal,Matthew A Hathcock,Arushi Khurana,N Nora Bennani,Yucai Wang,Jonas Paludo,Jose Villasboas Bisneto,Stephen M Ansell,Patrick B Johnston,Yi Lin,Jason N Barreto

Cancer medicine（2023）

引用 4|浏览19

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摘要

Elevated serum PCT concentrations above 0.4 ng/mL at time of first fever after CAR-T infusion was significantly associated with confirmed bacterial infection. Furthermore, rigorous, prospective studies should validate our findings and evaluate serial PCT measurements to optimize antimicrobial use after CAR-T therapy.

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关键词

T-cell,antibiotics,antimicrobial stewardship,chimeric antigen receptor,cytokine release syndrome,fever,immunotherapy,infection,procalcitonin

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