[New MDS Criteria for the Diagnosis of Multiple System Atrophy: A Clinicopathological Viewpoint].

Since its publication in 2008, several operational issues have emerged in the second consensus diagnostic criteria for multiple system atrophy (MSA). In fact, a small proportion of patients with other conditions, including Parkinson's disease or progressive supranuclear palsy, may be misdiagnosed as having MSA over the course of their life. In addition, it is necessary to identify patients with MSA with high accuracy, especially in the early stage of disease, to allow treatment. With the second consensus diagnostic criteria, however, the disease often reaches an advanced stage by the time of diagnosis. In this review, we focus on key modifications in the third consensus diagnostic criteria for MSA from a clinicopathological point of view.