Alzheimer's disease phenotypes show different sleep architecture.

Neus Falgàs,Christine M Walsh,Leslie Yack,Alexander J Simon,Isabel E Allen,Joel H Kramer, Howard J Rosen,Renaud La Joie,Gil Rabinovici,Bruce Miller,Salvatore Spina,William W Seeley,Kamalini Ranasinghe,Keith Vossel,Thomas C Neylan,Lea T Grinberg

Alzheimer's & dementia : the journal of the Alzheimer's Association（2023）

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摘要

Alzheimer's disease (AD) variants show distinct patterns of sleep impairment. Amnestic/typical AD has worse N3 slow wave sleep (SWS) impairment compared to atypical AD. Atypical AD shows more rapid eye movement deficits than typical AD. Selective vulnerability patterns in subcortical areas may underlie sleep differences. Relatively preserved SWS may explain better memory scores in atypical versus typical AD.

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关键词

Alzheimer's disease,locus coeruleus,neuromodulatory subcortical systems,selective vulnerability,sleep

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