Bilayer fixed-dose combination tablet for curcumin microparticles and piroxicam and i n vitro evaluation.

In the present work, fixed-dose combination of bilayer tablets for piroxicam as and curcumin as immediate-release and sustained-release layer (SRL) respectively for management of inflammatory response. The SRL include Curcumin polycaprolactone microparticles from spray drying. The tablet layers include Pearlitol 200SD, Microcrystalline cellulose PH101, Aerosil 200, talc each layer. SEM studies confirm spherical microparticles. PXRD and DSC studies confirm the amorphous microparticles. studies exhibit, an immediate release and sustained release for Piroxicam and Curcumin after 2 h. Cellular uptake studies on RAW 264.7 cells confirm the complete internalization of microparticles. Therefore, it was concluded that microparticles can be formulated into a unit dosage form for the management of inflammation.