HNRNPL induced circFAM13B increased bladder cancer immunotherapy sensitivity via inhibiting glycolysis through IGF2BP1/PKM2 pathway.

Jiancheng Lv,Kai Li,Hao Yu,Jie Han,Juntao Zhuang,Ruixi Yu,Yidong Cheng,Qiang Song,Kexin Bai,Qiang Cao,Haiwei Yang,Xiao Yang,Qiang Lu

Journal of experimental & clinical cancer research : CR（2023）

引用 5|浏览22

暂无评分

摘要

HNRNPL-induced circFAM13B could repress immune evasion and enhance immunotherapy sensitivity by inhibiting glycolysis and acidic TME in BCa through the novel circFAM13B/IGF2BP1/PKM2 cascade. Therefore, circFAM13B can be used as a biomarker for guiding the immunotherapy among patients with BCa.

查看译文

关键词

Bladder cancer,Glycolysis,IGF2BP1,Immunosensitivity,PKM2,circFAM13B

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要