Adipocyte-specific FXR-deficiency protects adipose tissue from oxidative stress and insulin resistance and improves glucose homeostasis

Hélène Dehondt, Arianna Marino,Laura Butruille,Denis A Mogilenko, Arielle C Nzoussi Loubota,Oscar Chávez-Talavera,Emilie Dorchies,Emmanuelle Vallez,Joel Haas,Bruno Derudas,Antonino Bongiovanni,Meryem Tardivel,Folkert Kuipers,Philippe Lefebvre,Sophie Lestavel,Anne Tailleux,David Dombrowicz,Sandrine Caron,Bart Staels

Molecular Metabolism（2023）

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摘要

•High fat diet-fed FXR-deficient mice display reduced inflammation in white adipose tissue.•An adipocyte-specific FXR-deficient mouse model has been generated.•Adipocyte FXR-deficiency protects white adipose tissue from inflammation.•Adipocyte FXR-deficiency improves glucose tolerance and insulin sensitivity.•The antioxidant enzyme Gsta4a is the most strongly induced gene in FXR-deficient adipocytes.

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关键词

White adipose tissue,Nuclear receptor FXR,Inflammation,Oxidative stress,Glucose metabolism

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