Systematic mapping of the conformational landscape and dynamism of soluble fibrinogen.

Jose E E Pinelo,Pragya Manandhar,Grega Popovic, Katherine Ray, Mehmet F Tasdelen,Quoc Nguyen,Anthony T Iavarone,Adam R Offenbacher,Nathan E Hudson,Mehmet Sen

Journal of thrombosis and haemostasis : JTH（2023）

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摘要

This work provides a molecular basis for the structural "dynamism" of fibrinogen that is expected to influence the broad swath of its functionally diverse macromolecular interactions and fine-tune the structural and mechanical properties of blood clots.

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关键词

conformational landscape,cryptic interactions,fibrinogen,fibrinogenemia,flexion,structural flexibility

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