Quantitative omics analyses of NCOA4 deficiency reveal an integral role of ferritinophagy in iron homeostasis of hippocampal neuronal HT22 cells.

Emily F Bengson,Cole A Guggisberg,Thomas W Bastian,Michael K Georgieff,Moon-Suhn Ryu

Frontiers in nutrition（2023）

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摘要

These findings identify an integral role of NCOA4-mediated ferritinophagy in the maintenance of iron homeostasis by HT22 cells, and its potential implications in controlling genetic pathways of neurodevelopment and neurodegenerative diseases.

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IRP2,RNA-seq,ferritin,ferritinophagy,iron deficiency,proteomics

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