Clinical significance of neoadjuvant chemotherapy for locally advanced colorectal cancer patients with deficient mismatch repair: possibly residual value in the era of immunotherapy.

Mian Chen,Junguo Chen,Jun Huang,Huashan Liu,Wuteng Cao,Shuangling Luo,Zhanzhen Liu,Huanxin Hu,Sicong Lai,Yujie Hou,Liang Kang,Liang Huang

Therapeutic advances in gastroenterology（2023）

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摘要

In this study, NAC was associated with better tumor downstaging and longer 5-year DFS in LACC patients with dMMR. Consequently, NAC might be an additional treatment choice when it comes to such patients in the future.

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deficient mismatch repair,locally advanced colorectal cancer,neoadjuvant chemotherapy,prognosis

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