Kazinol B protects H9c2 cardiomyocytes from hypoxia/reoxygenation-induced cardiac injury by modulating the AKT/AMPK/Nrf2 signalling pathway.

Qian Zhang,Yuan-Ye Dang,Xiu Luo,Ji-Jun Fu,Zhi-Cong Zou,Xue-Jing Jia,Guo-Dong Zheng,Chu-Wen Li

Pharmaceutical biology（2023）

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摘要

KB prevented H/R-induced cardiomyocyte injury via modulating the AKT and AMPK-mediated Nrf2 induction. KB might be a promising drug candidate for managing ischemic cardiac disorders.

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关键词

Broussonetia kazinoki,apoptosis,mitochondrial dysfunction,myocardial ischemia,oxidative stress

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