Salvage Surgery for Advanced Lung Adenocarcinoma After Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Treatment.

Mong-Wei Lin,Sung-Liang Yu,Yin-Chen Hsu,Yan-Ming Chen,Yi-Hsuan Lee,Yi-Jing Hsiao,Jing-Wei Lin,Te-Jen Su,Chi-Fu Jeffrey Yang,Xu-Heng Chiang,Hsao-Hsun Hsu,Jin-Shing Chen,Min-Shu Hsieh

The Annals of thoracic surgery（2023）

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摘要

The presence of morphologically treatment-resistant tumor regions with acquired T790M mutations and histologic transformations demonstrate the existence of resistant subclones in TKI-treated tumors before disease progression. Salvage surgery performed in selected patients before disease progression may improve survival by removing TKI-resistant subclones.

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关键词

Drug resistance,epidermal growth factor receptor,lung adenocarcinoma,salvage surgery,tyrosine kinase inhibitor

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