Assessment of superiority of HSP70-targeting aptamer-functionalized drug-nanocarrier over non-targeted commercially available counterpart in HCC therapy: in vitro and in vivo investigations and molecular modeling.

Samrat Chakraborty,Apala Chakraborty,Biswajit Mukherjee,Shila Elizabeth Besra,Saikat Dewanjee,Alankar Mukherjee,Ramkrishna Sen,Probir Kumar Ojha,Vinay Kumar,Tapan Kumar Shaw,Prasanta Ghosh,Mita Chatterjee Debnath,Miltu Kumar Ghosh

Life sciences（2023）

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摘要

The target-specificity of PTX-NPL5 towards neoplastic hepatocytes, probably achieved through HSP70 recognition, enhanced its therapeutic efficacy over CF, which may facilitate its real clinical deployment against HCC in the near future.

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关键词

Apoptosis,Aptamer,HSP70,Hepatocarcinogenesis,Paclitaxel,Targeted therapy

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