Single-cell RNA-Seq reveals CVI-mAb-induced Lyve1+ M2-like macrophages reduce atherosclerotic plaque area in Apoe-/- mice

Rui Duan,Yan Liu,Dongmei Tang,Sujun Xiao,Run Lin,Ming Zhao

International Immunopharmacology（2023）

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摘要

•CVI-mAb significantly increased M2-type macrophage differentiation in atherosclerotic mice.•CVI-mAb treatment could induce M2 macrophages to differentiate from S100a6+ Ccr2+ macrophages to Lyve1+ Abca1+ macrophages.•CVI-mAb induced Lyve1+ M2-like macrophages had functions of phagocytosis and lipid transport.•CVI-mAb induced Lyve1+ M2-like macrophages could reduce plaque areas in Apoe-/- mice fed high-fat diet.

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关键词

CVI-mAb therapy,Atherosclerosis,Single-cell RNA sequencing,Differentiation,Lyve1+ M2-like macrophages

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