Mapping cryptic binding sites of drug targets to overcome drug resistance.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy（2023）
摘要
The emergence of drug resistance is a primary obstacle for successful chemotherapy. Drugs that target cryptic binding sites (CBSs) represent a novel strategy for overcoming drug resistance. In this short communication, we explain and discuss how the discovery of CBSs and their inhibitors can overcome drug resistance.
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