Pathogenicity of Human Anti-PLA 2 R1 Antibodies in Minipigs: A Pilot Study.

Linda Reinhard,Thorsten Wiech, Aline Reitmeier,Moritz Lassé,Maya Machalitza,Asmus Heumann,Nicoletta Ferru,Desiree Loreth,Marie-Luise Schröder,Arvid Hutzfeldt, Felix R Stahl,Sven Peine,Hermann-Josef Gröne,Catherine Meyer-Schwesinger,Markus M Rinschen,Rolf A K Stahl,Elion Hoxha

Journal of the American Society of Nephrology : JASN（2023）

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摘要

A translational approach from humans to minipigs showed that human anti-PLA 2 R1 antibodies are pathogenic in MN, although in the heterologous phase of disease only low-level proteinuria developed.

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关键词

membranous nephropathy,PLA(2)R1,pathogenecity,complement,pilot projects,miniature swine

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