In vivo monitoring of vascularization and oxygenation of tumor xenografts using optoacoustic microscopy and diffuse optical spectroscopy.

K G Akhmedzhanova,A A Kurnikov,D A Khochenkov,Yu A Khochenkova, A M Glyavina,V V Kazakov,A V Yudintsev,A V Maslennikova,I V Turchin,P V Subochev,A G Orlova

Biomedical optics express（2022）

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摘要

The research is devoted to comparison of the blood vessel structure and the oxygen state of three xenografts: SN-12C, HCT-116 and Colo320. Differences in the vessel formation and the level of oxygenation are revealed by optoacoustic (OA) microscopy and diffuse optical spectroscopy (DOS) respectively. The Colo320 tumor is characterized by the highest values of vessel size and fraction. DOS showed increased content of deoxyhemoglobin that led to reduction of saturation level for Colo320 as compared to other tumors. Immunohistochemical (IHC) analysis for CD31 demonstrates the higher number of vessels in Colo320. The IHC for hypoxia was consistent with DOS results and revealed higher values of the relative hypoxic fraction in Colo320.

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关键词

optoacoustic microscopy,tumor xenografts,vivo monitoring,vascularization,optical spectroscopy

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